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Updated: Feb 10, 2026
12:02
Assays for the Identification of Novel Antivirals against Bluetongue Virus
Published on: October 11, 2013
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Chronic Hepatitis C and Direct Acting Antivirals
Maria Westerhoff1, Joseph Ahn2
1University of Michigan, 1301 Catherine Street, 5231 Medical Science Building 1, Ann Arbor, MI 48104, USA.
Surgical Pathology Clinics
|May 13, 2018
Summary
Hepatitis C virus (HCV) infection is a leading cause of liver disease. Recent direct-acting antiviral therapies have dramatically improved cure rates for HCV, offering new hope for patients.
Area of Science:
- Hepatology
- Virology
- Pathology
Background:
- Hepatitis C virus (HCV) is a major U.S. blood-borne pathogen.
- HCV is the primary cause of end-stage liver disease and liver transplant necessity.
- HCV treatment has seen significant advancements in the past decade.
Purpose of the Study:
- To provide pathologists and clinicians with an overview of HCV.
- To detail the histologic findings associated with HCV infection.
- To discuss the impact and application of direct-acting antiviral therapies for HCV.
Main Methods:
- Review of current literature on HCV pathology.
- Analysis of histologic features in HCV-infected patients.
- Examination of direct-acting antiviral treatment outcomes.
Main Results:
- Direct-acting antiviral therapies have increased HCV cure rates to over 90%.
- Histologic findings provide crucial diagnostic and prognostic information.
- Successful treatment significantly impacts liver disease progression.
Conclusions:
- Direct-acting antivirals represent a revolutionary advancement in HCV management.
- Understanding HCV histology is essential for accurate diagnosis and monitoring.
- Improved treatment outcomes underscore the importance of accessible care.
Keywords:
Diagnostic criteriaDirectly acting antiviralsHepatitis CHistologyLiver biopsyTransient elastographyMore Related Videos
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