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Therapeutic Applications of Mesenchymal Stem Cells for Systemic Lupus Erythematosus

Jianyong Xu1

  • 1Department of Immunology, Shenzhen University School of Medicine, Shenzhen University, Shenzhen, People's Republic of China. xujianyong@szu.edu.cn.

Advances in Experimental Medicine and Biology
|May 17, 2018
PubMed

Mesenchymal stem cells (MSCs) have been intensively studied and applied in regenerative medicine and tissue engineering. Recently, their immune modulation functions make them as attractive potential approaches for autoimmune disease treatment. Systemic lupus erythematosus (SLE) is one type of chronic autoimmune diseases with multi-organ damaged by the immune system. Although current available treatments are effective for some patients, others are refractory for these therapies. The immuno-modulatory and regenerative characteristics of MSCs make them as one promising candidate for treating SLE. Thus, we would discuss their immune modulation effects, pre-clinical and clinical applications, and the potentials for immune tolerance re-establishment in SLE here.

Keywords:
Autoimmune diseasesMSCsMesenchymal stem cellsSLESystemic lupus erythematosus

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