Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine
Maryam Rahmati1,2,3, Cristian Pablo Pennisi4, Ali Mobasheri5,6,7,8,9
1Cellular and Molecular Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Advances in Experimental Medicine and Biology
|May 17, 2018
Summary
Biomaterials like polymers, ceramics, and nano-biomaterials are being explored to improve stem cell therapy by enhancing cell survival and integration for tissue regeneration.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Stem Cell Biology
Background:
- Stem cell therapies show promise for tissue regeneration but face challenges with poor cell survival and engraftment after transplantation.
- Developing strategies to improve transplanted stem cell persistence and therapeutic efficacy is crucial for advancing regenerative medicine.
Purpose of the Study:
- To review the properties of various biomaterials, including polymers, ceramics, and nano-biomaterials, used in stem cell applications.
- To discuss approaches that mimic the stem cell microenvironment to better control stem cell fate and enhance therapeutic outcomes.
Main Methods:
- The chapter provides an overview of stem cell biology, sources, and their native microenvironment.
- It reviews recent studies on diverse biomaterials designed to support and guide transplanted stem cells.
Main Results:
- Biomaterials offer potential solutions to overcome limitations in stem cell transplantation, such as poor cell persistence.
- Investigating biomaterials that replicate the stem cell niche can lead to improved control over stem cell behavior.
Conclusions:
- Biomaterials are essential for enhancing the success of stem cell-based therapies by improving cell engraftment and longevity.
- Mimicking the stem cell microenvironment with advanced biomaterials is key to unlocking the full potential of regenerative medicine.
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