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Updated: Feb 10, 2026
Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
Development of coverage and its evaluation in the treatment of chronic wounds
Marcia Diana Umebayashi Zanoti1, Helena Megumi Sonobe2, Sidney José Lima Ribeiro3
1Universidade Estadual Paulista, Araraquara, SP, Brazil, ma.zanoti@bol.com.br.
Objectives:
To describe the development of the bacterial cellulose coating with anti-inflammatory Ibuprofen (BC/Ibu) and to evaluate the cicatrization process with its use in patients with chronic wounds of venous and diabetic etiology.
Methods:
Longitudinal descriptive study. The cellulose membrane, cultivated with bacteria Gluconacetobacter xylinus and with incorporation of Ibuprofen, was used in the treatment of patients with chronic wounds in public health services in a Brazilian municipality. The ideal coverage characteristics were evaluated through physical, chemical and cell proliferation tests.
Results:
The sample consisted of 14 patients (10 women and 4 men), 8 with venous ulcer, 5 with diabetic foot and one with mixed wound. There was reduction of area and pain in 9 lesions; total healing of 3 wounds; and debridement of the devitalized tissue in 5 wounds with increased area. The use of the membrane was important in the reduction of pain, exudation and ease in the accomplishment of the curative.
Conclusions:
BC/Ibu favored the cicatrization process of patients with chronic vasculogenic wounds.
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