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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Finding treatable genetic obesity: strategies for success

Kristin Dayton1, Jennifer Miller

  • 1Department of Pediatrics, University of Florida, Gainesville, Florida, USA.

Current Opinion in Pediatrics
|May 18, 2018
PubMed

Insights

Genetic obesity affects up to 7% of severe childhood cases. Current guidelines recommend screening, but most patients are not assessed for genetic obesity syndromes, delaying diagnosis and personalized treatment.

Area of Science:

  • Pediatric Endocrinology
  • Genetics
  • Metabolic Disorders

Background:

  • Genetic factors contribute significantly to severe childhood obesity, accounting for up to 7% of cases.
  • Pediatric Endocrine Society guidelines advocate for the assessment of genetic obesity syndromes in children with early-onset morbid obesity and hyperphagia.
  • A significant gap exists in the current screening practices, with a majority of eligible patients not being evaluated for genetic obesity.

Purpose of the Study:

  • To review the current landscape of genetic obesity syndromes in children.
  • To highlight the importance of identifying genetic causes for effective treatment strategies.
  • To discuss recent advances in genetic testing and emerging therapeutic options.

Main Methods:

  • Review of current literature on genetic obesity syndromes.
  • Analysis of diagnostic challenges and screening recommendations.
  • Exploration of novel and investigational therapeutic approaches.

Main Results:

  • Advances in genetic testing are continually identifying new genetic causes of obesity.
  • Individualized treatment strategies, targeting the specific genetic cause, are crucial for management.
  • Investigational therapies include melanocortin-4 receptor agonists, oxytocin, and endocannabinoid system modulators.

Conclusions:

  • Improved identification of genetic obesity syndromes is essential for developing personalized management plans.
  • Early and accurate diagnosis facilitates the development of targeted and effective treatments.
  • Personalized medicine approaches hold promise for improving outcomes in children with genetic obesity.
Abstract

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