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Evolution of Trichocyte Keratin Associated Proteins
1State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China. dongdongw86@yahoo.com.cn.
Advances in Experimental Medicine and Biology
|May 26, 2018
Summary
Keratin associated proteins (KRTAPs) are crucial for hair structure. Studying KRTAP gene variants can lead to enhanced wool and cashmere production in sheep and goats.
Area of Science:
- Animal Genetics
- Molecular Biology
- Biochemistry
Background:
- Hair's primary constituents are keratins and keratin associated proteins (KRTAPs).
- KRTAPs create the matrix between keratin intermediate filaments via disulfide bonds.
- The KRTAP gene family, comprising 100-180 genes, is vital in mammalian hair evolution.
Purpose of the Study:
- To investigate the role of KRTAP genes in mammalian hair structure.
- To explore the evolutionary patterns of the KRTAP gene family.
- To assess the potential of KRTAP gene variants for improving livestock breeding.
Main Methods:
- Bioinformatic analysis of KRTAP gene family evolution.
- Comparative genomics of KRTAP genes across mammalian species.
- Correlation analysis between KRTAP variants and fiber characteristics.
Main Results:
- KRTAP genes exhibit concerted evolution, mirroring mammalian hair evolution.
- KRTAP genes are significant in determining cashmere fiber structure in sheep and goats.
- Identified KRTAP gene variants offer insights into fiber quality traits.
Conclusions:
- KRTAP genes play a critical role in the structural integrity and evolution of mammalian hair.
- KRTAP gene variants are valuable genetic markers for selective breeding in sheep and goats.
- Further research into KRTAP genetics can optimize cashmere and wool production.
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