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Updated: Feb 9, 2026

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
Incobotulinumtoxin A for Sialorrhea in Neurological Disorders: A Real-Life Experience
Javier Martínez-Poles1, Velina Nedkova-Hristova2, José Bernardo Escribano-Paredes3
1Department of Neurology, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain. javimarpo@gmail.com.
Abstract:
Botulinum toxin type A is one of the most useful treatments of sialorrhea in neurological disorders. Evidence for the use of incobotulinumtoxin A (inco-A) in the treatment of sialorrhea is limited. Thirty-six patients with sialorrhea were treated with infiltrations of inco-A into both parotid glands. The severity of sialorrhea was evaluated by the Drooling Severity Scale (DSS), and the Drooling Frequency Scale (DFS). Patients' perceptions of clinical benefit were recorded via the Patient Global Impression of Improvement (PGI-I) scale. Following treatment, there was a significant difference in both the DFS and the DSS (p < 0.001). Clinical benefits on the basis of the PGI-I were present in up to 90% of patients.
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