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Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry
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Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry

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Comprehensive Tandem-Mass-Spectrometry Coverage of Complex Samples Enabled by Data-Set-Dependent Acquisition.

Corey D Broeckling1, Emmy Hoyes2, Keith Richardson2

  • 1Proteomics and Metabolomics Facility , Colorado State University , C-121 Microbiology Building 2021 Campus Delivery , Fort Collins , Colorado 80523 , United States.

Analytical Chemistry
|May 31, 2018
PubMed
Summary

Data-dependent MS/MS (DDA) struggles with comprehensive molecule coverage in complex samples. A new data-set-dependent MS/MS (DsDA) approach improves MS/MS sampling by integrating MS1 data processing and target prioritization for omics experiments.

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