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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Serum Bile Acids in Patients With Primary Open-angle Glaucoma
Mridula M Jacob1, Vijaya Pai H1, John Gnanaharan2
1Departments of Ophthalmology.
Journal of Glaucoma
|May 31, 2018
Summary
Serum bile acids (SBA) are elevated in primary open-angle glaucoma (POAG) patients. This finding suggests bile acids may contribute to POAG
Area of Science:
- Ophthalmology
- Biochemistry
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness globally.
- The exact pathophysiology of POAG remains incompletely understood, with oxidative stress and apoptosis implicated.
Purpose of the Study:
- To quantify serum bile acid (SBA) levels in patients diagnosed with POAG.
- To compare SBA levels between POAG patients and age-matched healthy controls.
Main Methods:
- A hospital-based case-control study involving 90 participants over 40 years old.
- Serum bile acids were measured using an ELISA kit enzymatic assay.
- Median SBA values were compared between the POAG group and the control group.
Main Results:
- Median SBA levels were significantly higher in patients with POAG compared to controls (P<0.001).
- Age and sex did not demonstrate a significant impact on median SBA levels within the study cohort.
Conclusions:
- Elevated serum bile acids may play a role in the pathogenesis of POAG.
- Further research is warranted to explore the specific mechanisms linking bile acids to oxidative stress and apoptosis in POAG.
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