The Microbiome in Psoriasis and Psoriatic Arthritis: Joints

Area of Science:

• Immunology
• Microbiology
• Gastroenterology

Background:

• The human microbiome plays a crucial role in modulating inflammatory disorders.
• Psoriatic diseases, including psoriasis and psoriatic arthritis, are linked to gut dysbiosis.
• Dysbiosis involves reduced beneficial commensals and altered fatty acid profiles.

Purpose of the Study:

• To review current literature on the microbiome's role in psoriatic diseases.
• To focus on synovio-entheseal inflammation in the context of the microbiome.
• To highlight potential diagnostic and therapeutic targets derived from microbe-host interactions.

Main Methods:

• Review of state-of-the-art literature presented at the GRAPPA 2017 annual meeting.
• Analysis of studies on intestinal and cutaneous microbes in psoriatic disease models and human samples.
• Synthesis of evidence regarding the physiological and pathogenic roles of the microbiome.

Main Results:

• Psoriatic diseases are characterized by intestinal dysbiosis.
• Evidence from animal models and human samples supports the link between dysbiosis and psoriatic disease.
• Microbe-host interactions are increasingly recognized for their role in health and disease.

Conclusions:

• The microbiome is a significant immunomodulator in psoriatic diseases.
• Understanding microbiome alterations can inform novel therapeutic strategies.
• Targeting microbe-host interactions presents a promising avenue for psoriatic disease management.