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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
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Related Experiment Video

Updated: Feb 9, 2026

High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem
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Postmortem fetal magnetic resonance imaging: where do we stand?

Aurélie D'Hondt1, Marie Cassart2, Raymond De Maubeuge1

  • 1Department of Radiology, Hôpital Delta (CHIREC), Boulevard du Triomphe 201, 1160, Auderghem, Belgium.

Insights Into Imaging
|June 6, 2018
PubMed
Summary

Postmortem fetal MRI (PFMRI) shows high accuracy in detecting fetal abnormalities compared to autopsy. This imaging technique is more acceptable to parents and can be integrated into routine clinical practice with proper training.

Keywords:
AutopsyFetusMagnetic resonance imagingPerinatalPostmortem

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Area of Science:

  • Medical Imaging
  • Radiology
  • Fetal Medicine

Background:

  • Postmortem fetal magnetic resonance imaging (PFMRI) is gaining traction due to its high concordance with histology.
  • Increasing parental refusal of traditional autopsy drives the adoption of alternative methods.
  • PFMRI has the potential to become a standard clinical examination.

Purpose of the Study:

  • To evaluate the contribution of PFMRI in diagnosing fetal anomalies.
  • To highlight the importance of standardized protocols and radiologist training for PFMRI.
  • To discuss the recognition of physiological postmortem changes in fetal imaging.

Main Methods:

  • Review of existing literature on PFMRI.
  • Analysis of clinical experience from a center routinely performing PFMRI.
  • Focus on concordance rates with autopsy and parental acceptability.

Main Results:

  • PFMRI demonstrates high concordance rates with autopsy in identifying fetal pathologies.
  • PFMRI is perceived as a more acceptable procedure by parents compared to autopsy.
  • The technique is increasingly utilized in postmortem investigations.

Conclusions:

  • PFMRI is a valuable tool for postmortem fetal investigations with high diagnostic accuracy.
  • Specialized training for radiologists is essential for accurate PFMRI interpretation.
  • PFMRI is feasible for routine clinical implementation in daily practice.