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[The expression of serum hepatocyte growth factor in OSAHS]

S L Zhou1, B Meng2, J H Ding3

  • 1Department of Respiration,Jiaxian People's Hospital,Jiaxian,467100，China.

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery
|June 6, 2018
PubMed

Insights

Hepatocyte growth factor (HGF) levels in peripheral blood increase with obstructive sleep apnea-hypopnea syndrome (OSAHS) severity. Detecting HGF aids in assessing OSAHS severity and cardiovascular disease risk.

Area of Science:

  • Cardiology
  • Pulmonology
  • Biochemistry

Background:

  • Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a prevalent condition associated with cardiovascular risks.
  • Hepatocyte growth factor (HGF) plays a role in tissue repair and angiogenesis.
  • The clinical significance of HGF in OSAHS remains to be fully elucidated.

Purpose of the Study:

  • To investigate the clinical significance of peripheral blood hepatocyte growth factor (HGF) detection in patients with OSAHS.
  • To correlate HGF levels with OSAHS severity and sleep respiration parameters.
  • To assess the impact of treatment on HGF levels in severe OSAHS.

Main Methods:

  • Ninety-six OSAHS patients were categorized into mild, moderate, and severe groups based on polysomnography (PSG) results.
  • Thirty-five healthy individuals served as the control group.
  • Enzyme-linked immunosorbent assay (ELISA) was used to measure peripheral blood HGF concentrations.

Main Results:

  • HGF concentrations were significantly elevated in OSAHS patients compared to controls, increasing with disease severity.
  • HGF levels showed a positive correlation with apnea-hypopnea index (AHI) and a negative correlation with lowest oxygen saturation (LSaO₂).
  • Comprehensive treatment in severe OSAHS patients led to significant reductions in HGF levels and AHI, alongside an increase in LSaO₂.

Conclusions:

  • Peripheral blood HGF levels are elevated in OSAHS patients and correlate positively with disease severity.
  • HGF serves as a potential biomarker for evaluating OSAHS severity, vascular endothelial dysfunction, and cardiovascular disease risk.
  • Monitoring HGF levels may aid in assessing treatment efficacy and patient prognosis.

Keywords:
hepatocyte growth factorsleep apnea hypopnea syndrome，obstructivevascular endothelial function

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