Durability, Behavior, and Tolerability of 5 Hyaluronidase Products
Gabriela Casabona1, Paula Barreto Marchese2, José Raúl Montes3
1Scientific Department, Ocean Clinic, Marbella, Spain.
Summary
Hyaluronic acid (HA) filler degradation varies significantly between different HA fillers and hyaluronidase (Hase) products. Practitioners must understand these differences for effective cosmetic treatments.
Area of Science:
- Cosmetic Dermatology
- Biochemistry
- Tissue Engineering
Background:
- Hyaluronic acid (HA) dermal fillers are widely utilized in cosmetic dermatology.
- Variations in HA filler concentration and cross-linking affect their susceptibility to hyaluronidase (Hase) degradation.
- The source and concentration of hyaluronidase (Hase) products influence their enzymatic activity.
Purpose of the Study:
- To compare the potency and activity of five different hyaluronidase (Hase) products.
- To evaluate the degradation of five distinct hyaluronic acid (HA) fillers in a human in vivo model.
Main Methods:
- A human in vivo model using excised skin from abdominoplasty was employed.
- Hyaluronic acid (HA) filler lumps were injected and subsequently treated with hyaluronidase (Hase) until complete degradation.
- Histological analysis of injected tissues was performed after repeated treatments.
Main Results:
- Significant variability was observed in the time and dose required for hyaluronidase (Hase) to degrade hyaluronic acid (HA) fillers.
- Degradation times ranged from less than 2 minutes to over 16 minutes, depending on the specific HA and Hase products used.
Conclusions:
- Cosmetic practitioners need to be aware of the distinct properties of various hyaluronic acid (HA) fillers and hyaluronidase (Hase) products.
- Understanding these differences is crucial for optimizing treatment outcomes and managing patient expectations in cosmetic dermatology.
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