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Updated: Feb 9, 2026
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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
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Cannabis users exhibit increased cortical activation during resting state compared to non-users
Shikha Prashad1, Elizabeth S Dedrick1, Francesca M Filbey1
1Center for BrainHealth, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.
Neuroimage
|June 13, 2018
Summary
Cannabis users show altered resting brain activity and connectivity compared to non-users. These changes in electroencephalography (EEG) signals may explain cognitive impairments and inform interventions.
Area of Science:
- Neuroscience
- Psychiatry
- Addiction Research
Background:
- Task-based brain activity is altered by cannabis use.
- Resting-state neural activity and functional organization in cannabis users are not well understood.
Purpose of the Study:
- To characterize resting-state cortical activity and functional connectivity in cannabis users using electroencephalography (EEG).
- To correlate these electrophysiological measures with cannabis use patterns.
Main Methods:
- Collected resting-state EEG (eyes-closed) from 17 cannabis users and 21 non-using controls.
- Analyzed power spectral density and spectral coherence across delta, theta, alpha, beta, and gamma frequency bands.
- Assessed network properties including mean network degree and clustering coefficient.
Main Results:
- Cannabis users showed decreased delta and increased theta, beta, and gamma power, indicating heightened cortical activation.
- Increased interhemispheric and intrahemispheric coherence was observed in cannabis users.
- Reduced network degree and increased clustering in specific regions/frequencies suggest altered neural organization and efficiency, a potentially 'noisy' brain.
Conclusions:
- Significant differences in resting-state cortical activity and functional connectivity exist between cannabis users and controls.
- These neurophysiological alterations are associated with cannabis use and may underlie cognitive impairments.
- Findings can inform the development and effectiveness of interventions for cannabis use disorder.
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