EBV-Encoded Latent Genes.
1Division of Microbiology, Faculty of Medicine, Tohoku medical and Pharmaceutical University, Sendai, Japan. tkanda@tohoku-mpu.ac.jp.
Advances in Experimental Medicine and Biology
|June 14, 2018
Summary
Epstein-Barr virus (EBV) latent genes are expressed in infected cells and contribute to cancers. This review clarifies their roles in B cell transformation and lymphomagenesis using genetic experiments.
Area of Science:
- Virology
- Oncology
- Molecular Biology
Background:
- Epstein-Barr virus (EBV) is a widespread human pathogen causing lifelong latent infections.
- Latent EBV infection can lead to various cancers, including lymphomas and epithelial carcinomas.
- EBV-encoded latent genes, including proteins and RNAs, are expressed during latency.
Purpose of the Study:
- To review the functions of EBV latent genes.
- To focus on functions verified by genetic experiments using EBV mutants.
- To summarize the contribution of latent genes to EBV-mediated diseases.
Main Methods:
- Review of scientific literature.
- Analysis of genetic experiments using EBV mutants.
- Summary of findings on EBV latent gene functions.
Main Results:
- EBV latent genes, including proteins and RNAs, are expressed in infected cells.
- Different expression patterns are observed in various EBV-infected cell types.
- Viral latent gene products are implicated in B cell transformation and carcinogenesis.
Conclusions:
- EBV latent genes play critical roles in EBV-associated B cell transformation and lymphomagenesis.
- Understanding latent gene functions is crucial for comprehending EBV-mediated tumorigenesis.
- Genetic validation of latent gene functions provides key insights into EBV pathogenesis.
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