Encyclopedia of EBV-Encoded Lytic Genes: An Update
1Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan. tmurata@fujita-hu.ac.jp.
Advances in Experimental Medicine and Biology
|June 14, 2018
Summary
Understanding Epstein-Barr virus (EBV) lytic genes is crucial for preventing viral spread and associated diseases. This review details EBV lytic genes, many of which are poorly understood and vital for viral propagation.
Area of Science:
- Virology
- Molecular Biology
- Infectious Diseases
Background:
- Epstein-Barr virus (EBV) is a human herpesvirus implicated in various diseases.
- Both latent and lytic genes of EBV are significant for viral lifecycle and pathogenesis.
- Lytic gene expression is essential for EBV propagation and associated disorders.
Purpose of the Study:
- To provide a comprehensive review of Epstein-Barr virus (EBV) lytic genes.
- To highlight the importance of EBV lytic genes in viral replication and disease.
- To address the current gaps in knowledge regarding EBV lytic gene products.
Main Methods:
- Literature review of scientific publications on EBV lytic genes.
- Analysis of existing research on EBV gene expression during different infection phases.
- Compilation of identified and putative EBV lytic gene products.
Main Results:
- EBV lytic genes are critical for viral propagation and disease development.
- Lytic genes are expressed during de novo infection and potentially during latency.
- Many EBV lytic gene products remain unidentified or misidentified in scientific literature.
Conclusions:
- Further research on EBV lytic genes is essential for developing therapeutic strategies.
- Accurate identification and characterization of EBV lytic genes are needed.
- Understanding EBV lytic gene function can aid in controlling EBV-associated diseases.
Related Concept Videos
01:30Lytic Cycle of Bacteriophages
78.1K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
78.1K
01:19Encoding
867
Information enters the brain through encoding, which is the input of information into the memory system. Once sensory information is received from the environment, the brain labels or codes it. The information is then organized with similar information and connected to existing concepts. Encoding occurs through automatic processing and effortful processing.
Automatic processing involves the encoding of details like time, space, frequency, and the meaning of words, usually done without conscious...
Automatic processing involves the encoding of details like time, space, frequency, and the meaning of words, usually done without conscious...
867
01:20Viral Replication: Lytic Cycle
1.7K
Bacteriophages, or phages, are viruses that specifically infect bacteria. Among them, T-even bacteriophages, such as T4, exhibit a well-characterized lytic replication cycle in Escherichia coli (E. coli). This process ensures the rapid proliferation of the virus while ultimately leading to the destruction of the bacterial host.Attachment and DNA InjectionThe infection process begins with the recognition and binding of the T4 phage to the E. coli cell surface. Tail fibers of the phage...
1.7K
02:07Organization of Genes
73.6K
Overview
73.6K
02:11Proteins: From Genes to Degradation
14.5K
Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick. Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA...
Transcription is the synthesis of RNA...
14.5K
02:05Gene Evolution - Fast or Slow?
8.2K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
8.2K