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PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay

Hyerim Yi1, Joha Park1, Minju Ha1

  • 1Center for RNA Research, Institute for Basic Science, Seoul 08826, Korea; School of Biological Sciences, Seoul National University, Seoul 08826, Korea.

Molecular Cell
|June 23, 2018
PubMed
Summary

The CCR4-NOT (CNOT) complex is a major deadenylase for cytoplasmic RNAs. Poly(A) binding protein (PABP) aids deadenylation, preventing premature decay and uridylation.

Keywords:
CAF1CCR4CCR4-NOTPABPCPAN2-PAN3PARNRNA decaydeadenylationpoly(A) tailuridylation

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