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Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
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[Study on lignans from Xanthii Fructus].

Hai Jiang1, Liu Yang1, Xu-Dong Xing1

  • 1Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang Key Laboratory of Traditional of Chinese Medicine and Natural Medicine Pharmacodynamic Material Bases, Heilongjiang University of Chinese Medicine, Harbin 150040, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|June 24, 2018
PubMed
Summary
This summary is machine-generated.

This study investigates lignans from Xanthium sibiricum fruits, identifying 17 compounds. New lignans were discovered in the Xanthium genus and Xanthii Fructus.

Keywords:
AsteraceaeXanthii FructusXanthiumchemical constituentlignans

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Area of Science:

  • Natural Product Chemistry
  • Phytochemistry
  • Organic Chemistry

Background:

  • Xanthium sibiricum (Xanthii Fructus) is traditionally used in medicine.
  • Lignans are a diverse class of phenolic compounds with various biological activities.
  • Previous research on Xanthium species has identified numerous bioactive compounds.

Purpose of the Study:

  • To isolate and identify lignans from the dried fruits of Xanthium sibiricum.
  • To characterize novel lignan compounds from this plant source.
  • To contribute to the understanding of the chemical diversity of Xanthium species.

Main Methods:

  • Extraction of chemical constituents using 70% ethanol.
  • Isolation and purification using silica gel, ODS, Sephadex LH-20, and MCI column chromatography.
  • Structure elucidation based on spectral data analysis and comparison with literature.

Main Results:

  • Seventeen lignan compounds were isolated and identified.
  • Compounds 2-17 represent the first isolation of lignans from the genus Xanthium.
  • Compound 1, (-)-pinoresinol, was isolated from Xanthii Fructus for the first time.

Conclusions:

  • The study successfully identified a range of lignans from Xanthium sibiricum.
  • This research expands the known phytochemical profile of the Xanthium genus.
  • The findings provide a basis for further investigation into the potential bioactivity of these lignans.