Left heart longitudinal deformation analysis in mitral regurgitation.
Matteo Cameli1, Giulia Elena Mandoli2, Dan Nistor3
1Department of Cardiovascular Diseases, University of Siena, Policlinico "Le Scotte", Viale Bracci 1, 53100, Siena, Italy. matteo.cameli@yahoo.com.
The International Journal of Cardiovascular Imaging
|June 28, 2018
Summary
Global peak atrial longitudinal strain (PALS) and global atrio-ventricular strain (GAVS) effectively predict mitral regurgitation (MR) severity in asymptomatic patients. These echocardiographic measures offer valuable insights into heart function beyond traditional assessments.
Area of Science:
- Cardiology
- Echocardiography
- Cardiac Imaging
Background:
- Left atrium (LA) and left ventricle (LV) remodel in mitral regurgitation (MR) even in asymptomatic patients.
- Accurate assessment of MR severity is crucial for timely intervention.
- Current methods may not fully capture functional changes in early-stage MR.
Purpose of the Study:
- To identify the optimal echocardiographic index for grading MR severity in asymptomatic individuals.
- To evaluate the utility of Speckle Tracking Echocardiography (STE)-derived strain parameters.
- To compare novel strain indices with conventional measures.
Main Methods:
- 150 asymptomatic MR patients (mild, moderate, severe) and 50 controls were enrolled.
- MR severity was quantified using Doppler echocardiography.
- Standard and STE analyses were performed, measuring global peak atrial longitudinal strain (PALS), LV longitudinal strain (LS), and global atrio-ventricular strain (GAVS).
Main Results:
- LA dimensions differed significantly across MR severity groups.
- PALS and GAVS demonstrated a significant inverse correlation with MR severity (p < 0.0001).
- PALS and GAVS were superior predictors of MR severity compared to LV longitudinal strain (GLS).
Conclusions:
- STE-derived PALS and GAVS are promising tools for assessing longitudinal heart function in asymptomatic MR.
- PALS provides added value to LA indexed volumes in predicting MR severity.
- These novel strain parameters can enhance the non-invasive evaluation of MR.
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