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A Microfluidic Chip for ICPMS Sample Introduction
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Introduction.

Chi Chun Wong1, Jun Yu2

  • 1Institute of Digestive Disease and Department of Medicine & Therapeutics, State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

Advances in Experimental Medicine and Biology
|June 30, 2018
PubMed
Summary
This summary is machine-generated.

Obesity is a growing global health issue linked to poor diet and inactivity. It significantly increases the risk of fatty liver disease and liver cancer (HCC), beyond its known links to diabetes and heart disease.

Keywords:
Hepatocellular carcinomaMicrobiotaNon-alcoholic steatohepatitisObesityTherapy

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Area of Science:

  • Public Health
  • Metabolic Disorders
  • Hepatology

Background:

  • The global obesity epidemic is escalating, driven by lifestyle factors like dietary changes and reduced physical activity.
  • Over two-thirds of adults in developed nations are overweight, with over a third classified as obese.
  • Obesity is a well-established risk factor for type II diabetes and cardiovascular diseases.

Discussion:

  • Emerging research highlights obesity as a critical risk factor for developing fatty liver diseases.
  • Obesity is increasingly implicated in the pathogenesis of hepatocellular carcinoma (HCC) originating from fatty liver conditions.
  • Understanding the link between obesity and liver disease progression is crucial for public health interventions.

Key Insights:

  • Obesity significantly elevates the risk of non-alcoholic fatty liver disease (NAFLD).
  • Fatty liver disease associated with obesity is a precursor to liver cancer (HCC).
  • Lifestyle modifications are essential to combatting the obesity epidemic and its associated health risks.

Outlook:

  • Further research is needed to elucidate the precise molecular mechanisms linking obesity to HCC.
  • Developing targeted therapies for obesity-related fatty liver disease is a priority.
  • Public health strategies must address lifestyle factors to mitigate the rising burden of obesity and liver disease.