Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

11.0K
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
11.0K
Tonsillitis II: Management01:26

Tonsillitis II: Management

439
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
439
Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

686
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
686
Impression Management Techniques I: Managing Appearances01:29

Impression Management Techniques I: Managing Appearances

220
Appearance is a multidimensional aspect of self-presentation that encompasses observable attributes such as clothing, grooming, speech, and nonverbal behavior. These elements are often strategically managed to align with socially constructed expectations in different settings. For instance, individuals tailor their appearance during job interviews, social gatherings, or athletic events to meet the perceived norms of those environments.Contextual Adaptation and Social SignalsThe research...
220
Types of RNA01:23

Types of RNA

72.9K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
72.9K
Types of Hormones02:13

Types of Hormones

83.7K
Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
83.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inpatient Outcomes of Pancreatic Cancer Surgery in Patients with Coronary Artery Disease.

Cancers·2026
Same author

Selective Cardioneuroablation for Symptomatic Sinus Bradycardia After Bariatric Surgery: A Report on two Cases.

Pacing and clinical electrophysiology : PACE·2026
Same author

Racial and Ethnic Disparities in the Management and Outcomes of Acute Myocardial Infarction Complicated by Ventricular Arrhythmias.

Journal of clinical medicine·2026
Same author

Reported Causes of Device Embolization Following Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.

The Permanente journal·2026
Same author

Contemporary Review of Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement with Concomitant Mitral Stenosis.

Current cardiology reviews·2025
Same author

Cardiogenic Shock With Acute Myocardial Infarction Among Older Adults in the United States.

JACC. Advances·2025
Same journal

Characteristics of Children Seeking Care at School-Based Health Centers.

Journal of the American Board of Family Medicine : JABFM·2026
Same journal

An Analysis of Common Questions and Concerns of Older Adults with Multiple Chronic Conditions.

Journal of the American Board of Family Medicine : JABFM·2026
Same journal

Primary HPV Testing for Cervical Cancer Screening Among Family Medicine Educators.

Journal of the American Board of Family Medicine : JABFM·2026
Same journal

"Hard Fork" for Family Medicine - Artificial Intelligence Will Change the Way We Experience Practice.

Journal of the American Board of Family Medicine : JABFM·2026
Same journal

The Importance of Primary Care Subject Matter Experts: Output Quality in Large Language Models Prompt Engineering.

Journal of the American Board of Family Medicine : JABFM·2026
Same journal

Daily Nutrient Intake and Inflammation Among US Adults.

Journal of the American Board of Family Medicine : JABFM·2026
See all related articles

Related Experiment Video

Updated: Feb 8, 2026

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
08:14

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

8.6K

Hyperlipidemia: Management with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors.

Muhammed Shahreyar1, Salem A Salem1, Mannu Nayyar1

  • 1From Division of Cardiology, Department of Medicine, University of Tennessee Health Sciences Center, Memphis, TN (MS, SAS, MN, NG, SKGK); Division of Nephrology, Department of Medicine, University of Tennessee Health Sciences Center, Memphis (LKG); Department of Physician Assistant Studies, University of Tennessee Health Sciences Center, Memphis (LKG); Regional One Health, Memphis (SKGK).

Journal of the American Board of Family Medicine : JABFM
|July 11, 2018
PubMed
Summary
This summary is machine-generated.

New proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors offer an alternative to statins for managing hyperlipidemia. These agents effectively lower low-density lipoprotein cholesterol, especially for statin-intolerant patients or those needing additional lipid reduction.

Keywords:
CholesterolCoronary Artery DiseaseHypolipidemic Agents

More Related Videos

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.8K
Quantification of Immunostained Caspase-9 in Retinal Tissue
05:18

Quantification of Immunostained Caspase-9 in Retinal Tissue

Published on: July 25, 2022

1.8K

Related Experiment Videos

Last Updated: Feb 8, 2026

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
08:14

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

8.6K
Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.8K
Quantification of Immunostained Caspase-9 in Retinal Tissue
05:18

Quantification of Immunostained Caspase-9 in Retinal Tissue

Published on: July 25, 2022

1.8K

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Coronary artery disease (CAD) is a leading cause of death in the U.S.
  • Hyperlipidemia is a significant, modifiable risk factor for CAD.
  • Statins are the primary pharmacologic treatment for hyperlipidemia due to their efficacy, safety, and cost-effectiveness.

Purpose of the Study:

  • To review proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors as a novel class of lipid-lowering agents.
  • To discuss the mechanism of action, indications, efficacy, safety, and limitations of PCSK9 inhibitors.
  • To highlight their role in managing hyperlipidemia, particularly for statin-intolerant patients or those with refractory hypercholesterolemia.

Main Methods:

  • Review of scientific literature and clinical trial data on PCSK9 inhibitors.
  • Analysis of their biological activity and impact on serum lipid levels.
  • Evaluation of safety profiles, cost-effectiveness, and clinical applications.

Main Results:

  • PCSK9 inhibitors significantly decrease low-density lipoprotein cholesterol (LDL-C) levels.
  • They provide an effective alternative for patients intolerant to statins.
  • PCSK9 inhibitors serve as valuable add-on therapy for patients not achieving LDL-C goals with statins alone.

Conclusions:

  • PCSK9 inhibitors represent a significant advancement in hyperlipidemia management.
  • They offer a crucial therapeutic option for specific patient populations.
  • Further research and real-world data will continue to define their long-term impact on cardiovascular outcomes.