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Updated: Feb 8, 2026

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
Flow chemistry-enabled studies of rhodium-catalyzed hydroformylation reactions
Cheng Zhu1, Keshav Raghuvanshi1, Connor W Coley2
1Department of Chemical and Biomolecular Engineering, North Carolina State University, 911 Partners Way, Raleigh, NC 27695, USA. abolhasani@ncsu.edu.
Abstract:
We present an automated microscale flow chemistry platform for rapid performance evaluation of continuous and discrete reaction parameters in homogeneous hydroformylation reactions. We demonstrate the versatility of the developed microfluidic platform through a systematic study of the effects of a library of phosphine-based ligands on catalytic activity and regioselectivity.
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