Related Experiment Video
Updated: Feb 8, 2026

05:29
A Rapid Screening Workflow to Identify Potential Combination Therapy for GBM using Patient-Derived Glioma Stem Cells
Published on: March 28, 2021
3.2K
Stem Cell Therapy of Gliomas.
Progress in Neurological Surgery
|July 11, 2018
Summary
Stem cells show promise as natural delivery vehicles for brain cancer gene therapy. Researchers are exploring various stem cell types and therapeutic agents for treating gliomas, with some approaches entering clinical trials.
Area of Science:
- * Regenerative Medicine
- * Cancer Gene Therapy
- * Neuro-oncology
Background:
- * Stem cells (SC) are investigated as tumor-tropic vectors for targeted gene delivery to solid tumors.
- * Stem cells possess inherent glioma tropism, making them suitable for delivering therapeutic agents to brain neoplasms.
- * Adult stem cells (ASC), particularly neural stem cells (NSC) and mesenchymal stem cells (MSC), are most studied for this application.
Purpose of the Study:
- * To review the potential of stem cells as vectors for gene delivery in treating brain tumors.
- * To summarize the types of therapeutic agents and stem cell carriers investigated for glioma treatment.
- * To assess the progress of stem cell-based glioma therapies towards clinical application.
Main Methods:
- * Review of preclinical studies investigating stem cell-mediated gene delivery for glioma.
- * Analysis of different types of adult stem cells utilized as therapeutic carriers.
- * Examination of various therapeutic cargoes delivered by stem cells, including proteins, viruses, and nanoparticles.
Main Results:
- * Multiple adult stem cell types, notably NSC and MSC, demonstrate glioma tropism.
- * A range of therapeutic cargoes, such as secreted proteins, suicide gene systems, oncolytic viruses, antibodies, and nanoparticles, have been tested.
- * Several preclinical stem cell-based glioma therapies have progressed to Phase I clinical trials.
Conclusions:
- * Stem cells offer a promising platform for targeted gene delivery to brain neoplasms.
- * The use of stem cells as carriers for antiglioma agents represents a potential future therapeutic strategy for glioma patients.
- * Continued research and clinical trials are essential to realize the full therapeutic potential of stem cell-based treatments for gliomas.
Related Concept Videos
Stem Cell Therapy for Tissue Regeneration
4.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.7K
Adult Stem Cells
33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
Embryonic Stem Cells
32.5K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.5K
Embryonic Stem Cells
5.1K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
5.1K
Induced Pluripotent Stem Cells
28.1K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.1K
Gene Therapy
27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K

