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Fixed dose 4-factor prothrombin complex concentrate for bleeding caused by long acting anticoagulant rodenticides
Richard J Doyle1, Zane Elfessi2, Kevin Kolman1
1Department of Emergency Medicine, Jesse Brown Veterans Affairs Medical Center, 820 S Damen Avenue, Chicago, IL 60612, United States of America.
The American Journal of Emergency Medicine
|July 14, 2018
Summary
Anticoagulant rodenticide poisoning is a serious concern. A case study shows that a fixed-dose of 4-factor prothrombin complex concentrate effectively reversed coagulation issues after acute ingestion.
Area of Science:
- Toxicology
- Emergency Medicine
- Clinical Pharmacology
Background:
- Acute, unintentional drug poisonings result in hundreds of thousands of emergency department visits annually.
- Anticoagulant rodenticides are a significant cause of rodenticide-related poisonings in the US.
- Established treatment protocols exist for anticoagulant rodenticide poisoning.
Purpose of the Study:
- To report a case of acute anticoagulant rodenticide ingestion.
- To evaluate the efficacy of a fixed-dose 4-factor prothrombin complex concentrate in reversing coagulopathy.
Main Methods:
- A patient with acute ingestion of two anticoagulant rodenticides was treated.
- A fixed-dose of 4-factor prothrombin complex concentrate was administered.
- Coagulation parameters were monitored to assess treatment effectiveness.
Main Results:
- Successful reversal of coagulation parameters was achieved.
- The fixed-dose 4-factor prothrombin complex concentrate demonstrated efficacy in this case.
Conclusions:
- 4-factor prothrombin complex concentrate can be a successful treatment for acute anticoagulant rodenticide poisoning.
- A fixed-dose approach may be a viable strategy for managing such poisonings.
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