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Updated: Feb 7, 2026
09:29
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
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Future Developments in Neoadjuvant Therapy for Triple-Negative Breast Cancer.
Lakisha Moore-Smith1, Andres Forero-Torres2, Erica Stringer-Reasor3
1Department of Medicine, Brookwood Baptist Health - Princeton, 833 Princeton Avenue, POB III Suite 200, Birmingham, AL 35211-1311, USA.
The Surgical Clinics of North America
|July 15, 2018
Summary
Triple-negative breast cancer (TNBC) remains a deadly subtype with few treatment options. Genomic profiling offers new hope for developing targeted therapies to improve patient outcomes.
Area of Science:
- Oncology
- Genomics
- Cancer Research
Background:
- Breast cancer is a leading cause of cancer death in women.
- Triple-negative breast cancer (TNBC) presents unique challenges due to limited targeted treatment options compared to other subtypes.
- Advances in targeted therapies have largely excluded TNBC, highlighting an unmet clinical need.
Purpose of the Study:
- To explore the potential of genomic profiling in identifying novel therapeutic targets for TNBC.
- To investigate the efficacy of personalized targeted agents in the neoadjuvant setting for TNBC patients.
- To understand mechanisms of resistance to current and novel therapies in TNBC.
Main Methods:
- Genomic profiling of TNBC tumors to identify actionable mutations and molecular alterations.
- Application of personalized targeted agents in the neoadjuvant treatment setting.
- Analysis of treatment response and resistance mechanisms through molecular and clinical data.
Main Results:
- Genomic profiling revealed promising molecular targets for TNBC.
- Personalized therapies demonstrated potential in the neoadjuvant setting, warranting further investigation.
- Insights into resistance mechanisms were gained, crucial for future treatment strategies.
Conclusions:
- Genomic profiling is a valuable tool for advancing TNBC treatment.
- Targeted therapies in the neoadjuvant setting hold promise for improving TNBC patient outcomes.
- Further research into molecular-based therapies is essential for overcoming treatment resistance in TNBC.
Keywords:
Early stage breast cancerNeoadjuvant chemotherapyTargeted therapyTriple-negative breast cancerMore Related Videos
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