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Corneal Manifestations of Systemic Sclerosis
Annamaria Nagy1, Aniko Rentka1, Gabor Nemeth1,2
1Department of Ophthalmology, Faculty of Medicine, University of Debrecen , Debrecen , Hungary.
Ocular Immunology and Inflammation
|July 18, 2018
Summary
Systemic sclerosis (SSc) patients show reduced corneal parameters, including thickness and volume, compared to healthy individuals. Early detection of these corneal changes is crucial for preventing vision loss.
Area of Science:
- Ophthalmology
- Rheumatology
- Connective Tissue Diseases
Background:
- Systemic sclerosis (SSc) is a connective tissue disease affecting collagen.
- Corneal involvement in SSc is uncommon but possible due to the cornea's collagen-rich structure.
- Ocular surface disorders, like dry eye disease (DED), can impact corneal health.
Purpose of the Study:
- To investigate and evaluate specific corneal parameters in patients diagnosed with systemic sclerosis.
- To compare corneal measurements between SSc patients and a control group without ocular symptoms.
- To assess the relationship between corneal changes and disease duration or patient age in SSc.
Main Methods:
- A cohort of 32 SSc patients and 39 healthy controls were recruited.
- Pentacam imaging was utilized for comprehensive corneal evaluation.
- Objective signs of dry eye disease (DED) and clinical parameters were assessed for all participants.
Main Results:
- SSc patients exhibited significantly lower pachymetric values, corneal volume, and anterior chamber depth compared to controls (p < 0.05).
- Corneal front surface measurements were also notably reduced in the SSc group.
- A significant negative correlation was observed between corneal parameters and both age and disease duration.
Conclusions:
- Corneal impairment represents a potential extraintestinal manifestation of systemic sclerosis.
- Reduced corneal parameters in SSc patients warrant early recognition during routine check-ups.
- Proactive monitoring of corneal health in SSc can help mitigate the risk of sight-threatening complications.
Keywords:
Autoantibody profileC-reactive protein (CRP)PentacamSchirmer-Icorneal thicknesscorneal volumedry eye testsystemic sclerosistBUTMore Related Videos
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