THE ROLE OF PROCALCITONIN AND BLOOD LACTIC ACID VALUES IN PROGNOSIS OF SEPSIS AND SEPTIC SHOCK IN POLYTRAUMA PATIENTS

Area of Science:

• Medical research
• Biomarker analysis
• Critical care medicine

Background:

• Polytrauma patients are susceptible to sepsis and septic shock.
• Biomarkers like Procalcitonin and Blood Lactic Acid are explored for infection management.
• Early detection and management are crucial for improving outcomes.

Purpose of the Study:

• To investigate the dynamic changes of Procalcitonin and Blood Lactic Acid in polytrauma patients with sepsis/septic shock.
• To correlate biomarker levels with trauma type, patient outcomes, and inflammatory markers.
• To assess the utility of these biomarkers in early evaluation and management.

Main Methods:

• Studied 21 polytrauma patients who developed sepsis/septic shock.
• Monitored dynamic levels of Procalcitonin and Blood Lactic Acid every 5 days for 45 days.
• Utilized Pearson correlation to analyze relationships with White Blood Cells (WBC), C-reactive protein (CRP), and Lymphocytes (LYM).

Main Results:

• Blood Lactic Acid normalized with optimized ventilation/oxygen therapy and correlated positively with recovery.
• Procalcitonin levels increased within 72 hours, peaked within 25 days, and indicated illness severity.
• Procalcitonin showed strong positive correlation with WBC and CRP, and negative correlation with LYM.

Conclusions:

• Blood Lactic Acid normalization is a positive prognostic indicator in polytrauma sepsis.
• Procalcitonin serves as a key indicator of sepsis severity, correlating with systemic inflammation.
• These biomarkers, alongside inflammatory factors, are valuable for early sepsis evaluation and management in polytrauma.