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Brinzolamide-induced Follicular Conjunctivitis
Jonathan W Young1, John L Clements1, John C Morrison1
1Casey Eye Institute, Oregon Health and Science University, Portland, OR.
Journal of Glaucoma
|August 23, 2018
Summary
Severe follicular conjunctivitis can develop from long-term brinzolamide use. Rechallenge confirmed the link, marking the first reported case of this adverse reaction to brinzolamide eye drops.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Brinzolamide is a topical carbonic anhydrase inhibitor commonly prescribed for glaucoma.
- Ocular side effects of brinzolamide are typically mild and transient.
Observation:
- A patient developed severe follicular conjunctivitis after 1.5 years of consistent brinzolamide use.
- Symptoms resolved upon discontinuation of the medication.
Findings:
- The patient was rechallenged with brinzolamide after symptom resolution.
- Recurrence of severe follicular conjunctivitis confirmed brinzolamide as the causative agent.
- This represents the first documented case of brinzolamide-induced follicular conjunctivitis.
Implications:
- Clinicians should be vigilant for ocular inflammatory reactions with long-term brinzolamide therapy.
- This case highlights the potential for delayed-onset hypersensitivity reactions to topical medications.
- Consider brinzolamide-induced conjunctivitis in patients presenting with persistent follicular conjunctivitis.
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