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An Explant System for Time-Lapse Imaging Studies of Olfactory Circuit Assembly in Drosophila
Published on: October 13, 2021
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Developmental Coordination during Olfactory Circuit Remodeling in Drosophila.
Oded Mayseless1, Dominic S Berns2, Xiaomeng M Yu2
1Department of Molecular Cell Biology, Weizmann Institute of Sciences, Rehovot 76100, Israel.
Neuron
|August 28, 2018
Summary
Neuronal circuit remodeling during development is coordinated. Inhibiting pruning in one neuron type, like mushroom body ɣ-neurons, prevents pruning in its synaptic partner, the anterior paired lateral neuron, affecting circuit wiring.
Area of Science:
- Neuroscience
- Developmental Biology
- Cell Biology
Background:
- Proper nervous system wiring relies on developmental neuronal remodeling.
- While individual neuronal remodeling is understood, coordinated circuit remodeling remains unclear.
Purpose of the Study:
- Investigate coordinated remodeling between synaptic partners in Drosophila.
- Determine if remodeling of the anterior paired lateral (APL) neuron and mushroom body (MB) ɣ-neurons is coordinated.
Main Methods:
- Simultaneous genetic manipulation of APL and MB ɣ-neurons during Drosophila metamorphosis.
- Analysis of neuronal pruning and synaptic connections using advanced imaging techniques.
- Investigating the role of Ca2+-Calmodulin signaling and neuronal activity.
Main Results:
- APL neuron remodeling is coordinated with MB ɣ-neuron remodeling.
- Inhibiting ɣ-neuron pruning cell-autonomously inhibits APL pruning.
- This coordination is partly mediated by Ca2+-Calmodulin and neuronal activity.
- Ectopic MB ɣ axons form aberrant connections with APL and other neurons.
Conclusions:
- Neuronal remodeling within circuits is coordinated.
- Inhibiting remodeling in one neuron type impacts the entire micro-circuit's functional wiring.
- This highlights the importance of precise developmental remodeling for neural circuit integrity.
Keywords:
APLDrosophilaMBactivityaxon pruningcalmodulincircuit remodelingmushroom bodyneuronal remodelingsynapse eliminationMore Related Videos
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