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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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Molecular and Cellular Requirements for the Assembly of Tertiary Lymphoid Structures
C G Mueller1, S Nayar2, J Campos2
1CNRS UPR 3572, Laboratory of Immunopathology and Therapeutic Chemistry/Laboratory of Excellence MEDALIS, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, Strasbourg, France.
Advances in Experimental Medicine and Biology
|August 30, 2018
Summary
Tertiary lymphoid structures (TLSs) form at chronic inflammation sites, mimicking secondary lymphoid organs (SLOs). This review details TLS structural components and signaling pathways driving their aggregation and function.
Area of Science:
- Immunology
- Pathology
Background:
- Immune cells form lymphoid-like structures at chronic inflammation sites.
- These structures, known as tertiary lymphoid structures (TLSs), resemble secondary lymphoid organs (SLOs).
- TLS formation is linked to disease persistence and systemic manifestations.
Purpose of the Study:
- To review the structural elements of TLSs.
- To identify the signaling pathways regulating TLS formation.
- To provide an overview of this complex immunological phenomenon.
Main Methods:
- Literature review of studies on TLS formation.
- Analysis of structural and signaling components of TLSs.
- Comparison of TLS and SLO formation mechanisms.
Main Results:
- TLSs exhibit segregated T- and B-cell areas, high endothelial venules (HEVs), and activated stromal cells.
- B-cell proliferation and affinity maturation occur within TLSs.
- Pro-inflammatory cytokines are implicated in TLS formation at various anatomical sites.
Conclusions:
- TLSs share histological similarities with SLOs but diverge in regulatory signals.
- Understanding TLS structure and signals is crucial for comprehending their role in disease.
- Further research into TLS formation mechanisms can inform therapeutic strategies.
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