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Updated: Feb 6, 2026

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods
Published on: May 2, 2016
Growing gold nanostructures for shape-selective cellular uptake.
Sulalit Bandyopadhyay1, Birgitte H McDonagh2, Gurvinder Singh3
1Ugelstad Laboratory, Department of Chemical Engineering, Norwegian University of Science and Technology (NTNU), N-7491, Trondheim, Norway. sulalit.bandyopadhyay@ntnu.no.
Gold nanostructures (NSs) interact differently with cancer cells. Researchers found that the shape of gold nanostructures, particularly the novel nanomakura, significantly influences their cellular uptake mechanisms in glioblastoma cells.
Area of Science:
- Nanomedicine
- Materials Science
- Cell Biology
Background:
- Gold nanostructures (Au NSs) are crucial in nanomedicine.
- Understanding Au NSs' interaction with cancer cells is a key challenge.
Purpose of the Study:
- To investigate the interaction of five different Au NS shapes with glioblastoma-astrocytoma cells.
- To determine the influence of Au NS shape on cellular uptake and cytotoxicity.
Main Methods:
- Synthesized Au NSs (nanorods, tetrahexahedra, bipyramids, nanomakura, spheres) using seed-mediated and Turkevich methods.
- Functionalized NSs with thiolated PEG and 11-Mercaptoundecanoic acid.
- Assessed cytotoxicity using LIVE/DEAD assay and uptake via Transmission Electron Microscopy (TEM).
Main Results:
- Au NS shape and concentration affected cytotoxicity in glioblastoma cells.
- Novel nanomakura NSs were synthesized and characterized.
- Nanomakura exhibited unique uptake via receptor-mediated endocytosis and macropinocytosis.
Conclusions:
- Au NS shape is a critical determinant of cellular uptake mechanisms.
- Nanomakura show distinct cellular interactions compared to other tested shapes.
- Shape-dependent cellular uptake is crucial for nanomedicine applications.
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