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The Cancer Genome Atlas Project in Bladder Cancer

Alejo Rodriguez-Vida1, Seth P Lerner2, Joaquim Bellmunt3,4

  • 1Medical Oncology Department, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Hospital del Mar, Barcelona, Spain.

Cancer Treatment and Research
|September 1, 2018
PubMed

Insights

Bladder cancer (BC) is aggressive, but new genomic insights from The Cancer Genome Atlas (TCGA) project offer hope. Expanded analyses reveal molecular targets for developing precision medicine to treat advanced urothelial carcinoma.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Bladder cancer (BC) presents a poor prognosis, particularly in metastatic stages, with limited survival.
  • Urothelial carcinomas exhibit frequent molecular alterations, suggesting potential therapeutic targets.
  • Current treatments for advanced BC lack molecularly targeted agents.

Purpose of the Study:

  • To review genomic alterations in bladder cancer from The Cancer Genome Atlas (TCGA) project.
  • To highlight new findings from an expanded TCGA analysis including 412 patients.
  • To inform the design of precision medicine for advanced bladder cancer treatment.

Main Methods:

  • Analysis of comprehensive integrated genomic data from The Cancer Genome Atlas (TCGA).
  • Review of previously reported and newly identified genomic alterations in bladder cancer.
  • Examination of genetic and epigenetic alterations using high-throughput genome analysis.

Main Results:

  • The updated TCGA analysis includes 412 patients, expanding on the initial 2014 study of 131 patients.
  • Identification of recurrent mutations and copy number alterations as potential therapeutic targets.
  • New major highlights from expanded genomic analyses are presented.

Conclusions:

  • Comprehensive genomic analysis is critical for advancing bladder cancer treatment.
  • Understanding the molecular landscape of BC can guide the development of targeted therapies.
  • Precision medicine approaches informed by TCGA data hold promise for improving outcomes in advanced bladder cancer.
Keywords:
Cancer genomicsMolecular biomarkersMolecular subtypesMolecular therapeutic targetsMutational loadThe cancer genome atlas projectUrothelial carcinomaWhole-genome and RNA sequencing

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