Related Experiment Video

Updated: Feb 5, 2026

Freeze-Fracture Electron Microscopy for Extracellular Vesicle Analysis
11:30

Freeze-Fracture Electron Microscopy for Extracellular Vesicle Analysis

Published on: September 16, 2022

4.5K

EXTRACELLULAR VESICLES FROM BLOOD PLASMA STUDIED BY LOW VOLTAGE SCANNING ELECTRON MICROSCOPY

K A Kondratov, T A Petrova, V Yu Mikhailovskii

    Tsitologiia
    |September 6, 2018
    PubMed

    More Related Videos

    Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix10:21

    Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

    Published on: June 14, 2016

    10.6K
    Techniques for the Analysis of Extracellular Vesicles Using Flow Cytometry09:39

    Techniques for the Analysis of Extracellular Vesicles Using Flow Cytometry

    Published on: March 17, 2015

    24.0K

    Related Concept Videos

    Scanning Electron Microscopy01:07

    Scanning Electron Microscopy

    A scanning electron microscope (SEM) is used to study the surface features of a sample by using an electron beam that scans the sample surface in a two-dimensional manner. Typically, areas between ~1 centimeter to 5 micrometers in width can be imaged. SEM can be used to image bacteria, viruses, tissues as well as larger samples like insects. Conventional SEM gives a magnification ranging from 20X to 30,000X and spatial resolution of 50 to 100 nanometers.
    Fundamental Principles
    Accelerated...
    5.5K
    Composition of Blood Plasma01:24

    Composition of Blood Plasma

    Blood plasma is a fluid that contains approximately 92% water and 8% solutes. The solutes include various types of proteins, which constitute about 7% of the total solutes in the plasma. The high-molecular-weight proteins—albumins, globulins, and fibrinogen—are essential to plasma function. Albumins, making up about 60% of the plasma proteins, maintain the osmotic balance within blood vessels by preventing excessive water leakage. Additionally, albumins serve as carrier proteins,...
    8.6K
    Fusion of Secretory Vesicles with the Plasma Membrane01:26

    Fusion of Secretory Vesicles with the Plasma Membrane

    Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
    In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
    18.9K
    Overview of Electron Microscopy01:25

    Overview of Electron Microscopy

    The wavelengths of visible light ultimately limit the maximum theoretical resolution of images created by light microscopes. Most light microscopes can only magnify 1000X, and a few can magnify up to 1500X. Electrons, like electromagnetic radiation, can behave like waves, but with wavelengths of 0.005 nm, they produce significantly greater resolution up to 0.05 nm as compared to 500 nm for visible light. An electron microscope (EM) can create a sharp image that is magnified up to 2,000,000X.
    14.8K
    Transmission Electron Microscopy01:15

    Transmission Electron Microscopy

    In 1931, physicist Ernst Ruska—building on the idea that magnetic fields can direct an electron beam just as lenses can direct a beam of light in an optical microscope—developed the first prototype of the electron microscope. This development led to the development of the field of electron microscopy. In the transmission electron microscope (TEM), electrons are produced by a hot tungsten element and accelerated by a potential difference in an electron gun, which gives them up to 400...
    7.3K
    Immunogold Electron Microscopy01:20

    Immunogold Electron Microscopy

    Immunoelectron microscopy utilizes immunogold labeling of endogenous proteins with specific antibodies to detect and localize these proteins in cells and tissues. The procedure provides insights into the distribution and quantification of protein under different stimulation conditions offering clues about their functions. Conjugating highly electron-dense gold particles with primary or secondary antibodies allow antigen detection on and within cells, with high resolution and specificity.
    5.5K