[MANAGEMENT OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN THE PREPREGNANCY AND ANTENATAL PERIODS: CHALLENGES AND...

Systemic lupus erythematosus (SLE) is a rare, multi-systemic chronic autoimmune disease characterized by hyperproduction of organ-specific autoantibodies to various components of the cell nucleus with the development of immuno-inflammatory damage of tissues and internal organs, predominantly affecting women, particularly those of childbearing age. Hence future pregnancy is one of the key issues of the modern rheumatology. The management of the SLE patient should include an effective risk assessment of the future pregnancy and stratification followed by an individualized antenatal care program. Timely detection of exacerbations and complications (medical and/or obstetric) is the leading prerogative of pregnancy management in SLE patients with the involvement of relevant practitioners. The purpose of our study was a review of literature related to the patients with SLE management by rheumatologists, obstetrician-gynecologists in prepregnancy and antenatal periods. The systematization of approaches to the management of SLE patients during these periods has been carried out, allowing practitioners to effectively assign appropriate diagnostic manipulations and timely safe treatment.