MARKERS OF THE LUNG CANCER COMPLICATIONS

Lung cancer (LC) occupies the first place in the structure of cancer morbidity and its prevalence is growing every year. Prognosis of LC course and its complications is a topical task of modern oncology. Further improvement of laboratory prognostic criteria for LC diagnosis and reliable markers of complications of the disease are necessary. Objective - to assess the significance of separate tumor markers in the context of diagnosis and prediction of LC complications. 1071 patients were examined (83% of men and 17% of women aged 24 to 86, average age - 59 years old). Central form of LC was found in 79% of the examined patients, peripheral - in 21% , small-cell histological variant of the disease was detected in 18% of cases and non-small-cell - in 82% (among which adenocarcinoma was detected in 47% of cases, squamous cell carcinoma - in 41%, large-cell carcinoma - in 12%). The ratio of IA, IB, IIA, IIB, III, III and IV stages of the disease was 1: 2: 4: 11: 117: 79: 120. In patients with LC there are increased values of such tumor markers as transforming growth factor β1, vascular endothelial growth factor, C-reactive protein, osteopontin, osteocalcin, a2-macroglobulin, fibronectin, bulk viscosity of serum, its surface elasticity, tension and relaxation, which is determined by the form of the disease (central, peripheral), its histological variant (small-cell, adenocarcinoma, squamous cell and large-cell carcinoma), the degree of differentiation and the integrated severity of the tumor process, features of metastasis. With the studied immuno-biochemical and physico-chemical tumor adsorption-rheological markers, which correlate with each other, the nature of primary tumor complications (exudative pleurisy, compression syndrome, obstructive atelectasis) is closely related. Values of osteopontin and bulk viscosity have prognostic significance as to relatively unfavorable course of LC, and a high level of surface viscosity is a risk factor for possible complications of the disease.