INVESTIGATION OF PROTECTIVE EFFECTS OF SYNBIOTICS ON ALLERGOPATHY FORMATION

A strategic direction of modern medicine in combating allergy is the search for new methods of primary prophylaxis, among which a key role may belong to normalization of the human body microflora. The aim of the research was to study the influence of synbiotics on bacteriological and immune indices in premature infants evaluating their preventive role in allergopathy formation. During prospective cohort investigation, 88 babies from one to four months of age, born on the 27th to 37th week of gestation to healthy mothers and women with allergopathy, were examined. Routine laboratory, bacteriological and instrumental investigations were performed. Measuring total serum IgE, cytokines IL-5, IL-10 and TNF-alpha in coprofiltrates was performed by means of immunoenzymatic assay. The activity of histaminase was detected by means of "Histamine 50-Skin-Prick Test". All examined patients were divided into four groups, depend on parents's atopic disease and prescribing synbiotics. For month, children from the first and the third groups were administered a commercial synbiotic - nutritional supplement with probiotics and fructooligosaccharides in the dose: one billion viable microencapsulated bacteria Lactobacillus rhamnosus GG in combination with fructooligosaccharides. Children from the second and the fourth groups were not administered synbiotic. Control of indices was conducted after 4 weeks. On bacteriological analysis of feces, the number of lacto- and bifidobacteria increased by 30% in children from the first and the third groups. Indices of total serum IgE were within age norm both before intake of synbiotic (1-2 groups) and after treatment. A reliable (p≤0.01) reduction of TNF-alpha and increase in IL-10 was revealed in coprofiltrates of children, who received synbiotic Preema sachet. Inclusion of synbiotic, which contains one billion viable microencapsulated bacteria Lactobacillus rhamnosus GG in combination with fructooligosaccharides to complex therapy of premature children results in regulation of cytokine balance with the tendency to reduction of an inflammatory process and has a preventive effect concerning allergopathy formation.