ASTHMA PREDICTIVE INDEX AND NITRIC OXIDE PROGNOSTIC VALUE IN YOUNG CHILDREN WITH RECURRENT WHEEZING

The study was aiming at investigation of Asthma Predictive Index (API) and predictive value of quantitative changes in nitric/nitrogen oxide (NO) in children with recurrent wheezing of different phenotypes. An observing cross-sectional clinical study where 120 patients 5 to 7 years of ages with wheezing syndrome were involved has been conducted. In the group of patients with multifactorial wheezing, 77%-positive results revealed in 65% of patients indicated to high probability of asthma formation. 59%-positive response to the API index prevailed in patients with episodic wheezing (28%). 77%-positive response sensitivity was 81% and specificity -93%, respectively. The increase in NO concentration (27.8±0.71) was fixed in 27.5% of patients with multifactorial wheezing, especially at 77% positive response to the API index. Measurement of API index and NO levels at early ages to reveal the contingent with high probability of asthma formation, especially in young children with multifactorial wheezing is of great importance.