Related Experiment Video

Updated: Feb 5, 2026

Analytical Techniques for Assaying Nitric Oxide Bioactivity
11:28

Analytical Techniques for Assaying Nitric Oxide Bioactivity

Published on: June 18, 2012

18.5K

ASTHMA PREDICTIVE INDEX AND NITRIC OXIDE PROGNOSTIC VALUE IN YOUNG CHILDREN WITH RECURRENT WHEEZING

T Mikeladze1, L Zhorzholiani1, L Saginadze1

  • 1Davit Aghmashenebeli University of Georgia; Institute of Pediatrics - Allergy Center, Evex Regional Hospital, Clinic CURACIO, Tbilisi, Georgia.

Georgian Medical News
|September 12, 2018
PubMed

Insights

The Asthma Predictive Index (API) and nitric oxide (NO) levels can identify children at high risk for developing asthma, particularly those with multifactorial wheezing. Early measurement aids in predicting asthma formation in young children.

Area of Science:

  • Pediatrics
  • Respiratory Medicine
  • Clinical Diagnostics

Background:

  • Recurrent wheezing in children presents diagnostic challenges.
  • Identifying early markers for asthma development is crucial for timely intervention.
  • Different phenotypes of wheezing may have varying asthma progression rates.

Purpose of the Study:

  • To investigate the Asthma Predictive Index (API) for predicting asthma.
  • To evaluate the predictive value of quantitative changes in nitric oxide (NO) levels.
  • To analyze these markers in children with recurrent wheezing of different phenotypes.

Main Methods:

  • A cross-sectional clinical study involving 120 children aged 5-7 years with wheezing syndrome.
  • Assessment of Asthma Predictive Index (API) response rates across different wheezing phenotypes.
  • Measurement of fractional exhaled nitric oxide (FeNO) levels and correlation with API results.

Main Results:

  • A 77% positive API response in 65% of multifactorial wheezing patients indicated high asthma probability.
  • Episodic wheezing patients showed a 59% positive API response (28% prevalence).
  • Elevated NO levels (27.8±0.71) were observed in 27.5% of multifactorial wheezing patients, correlating with a 77% positive API response; API demonstrated 81% sensitivity and 93% specificity.

Conclusions:

  • API and NO measurements are valuable tools for early asthma risk identification in children.
  • Early assessment is particularly important for children with multifactorial wheezing.
  • These markers can help identify children with a high probability of developing asthma.

More Related Videos

Platelet-based Detection of Nitric Oxide in Blood by Measuring VASP Phosphorylation07:13

Platelet-based Detection of Nitric Oxide in Blood by Measuring VASP Phosphorylation

Published on: January 7, 2019

8.5K
Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

4.8K

Related Concept Videos

Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
6.3K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.5K
Oxidation Numbers03:14

Oxidation Numbers

In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
42.8K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.4K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.2K
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

VSEPR Theory for Determination of Electron Pair Geometries
46.0K