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Updated: Feb 5, 2026
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Protocol for Biofilm Streamer Formation in a Microfluidic Device with Micro-pillars
Published on: August 20, 2014
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Intussusceptive Pillar Formation in Developing Porcine Glomeruli.
Anastasia Logothetidou1, Ward De Spiegelaere1, Tim Vandecasteele1
1Department of Morphology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Journal of Vascular Research
|September 14, 2018
Summary
Intussusceptive angiogenesis involves intraluminal pillars. This study reveals extracellular matrix deposition precedes perivascular cell involvement in forming these pillars during kidney vascular growth.
Area of Science:
- Vascular biology
- Developmental biology
- Renal physiology
Background:
- Intussusceptive angiogenesis (IA) drives vascular expansion and remodeling.
- Intraluminal pillars are key indicators of IA, but their formation mechanism is unclear.
Purpose of the Study:
- To investigate the cellular and structural components involved in the formation of intraluminal pillars during IA.
- To elucidate the early stages of intraluminal pillar development in the porcine metanephric kidney.
Main Methods:
- Light and electron microscopy were employed.
- The study focused on the developing porcine metanephric kidney vasculature.
Main Results:
- Nascent intraluminal pillars (< 2.5 µm diameter) were observed in glomerular capillaries, primarily composed of endothelial cells.
- Mature pillars with an extracellular matrix (ECM) core, covered by endothelium, were identified.
- Perivascular cells or pericytes were not involved in the observed pillar structures during formation.
Conclusions:
- Extracellular matrix (ECM) is present in mature intussusceptive pillars without perivascular cell involvement.
- A hypothesis is proposed: ECM deposition precedes perivascular cell participation in intraluminal pillar formation during IA in glomerular capillaries.
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