Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Contact Angle01:13

Contact Angle

20.6K
When a solid is dipped inside a liquid, the liquid surface becomes curved near the contact. For some solid–liquid interfaces, the liquid is pulled up along the solid, while for others, the liquid surface is convex or depressed near the solid surface. This phenomenon can be explained using the concept of cohesive and adhesive forces.
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...
20.6K
Contact-dependent Signaling01:19

Contact-dependent Signaling

47.5K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
47.5K
Association Areas of the Cortex01:21

Association Areas of the Cortex

9.4K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.4K
Associative Learning01:27

Associative Learning

1.3K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
1.3K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.7K
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

2.7K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A nationwide multi-centre survey of 12,500 cases of upper gastrointestinal bleeding: A report of Indian Society of Gastroenterology Task Force on acute upper gastrointestinal bleed.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·2026
Same author

Electroretinographic evaluation of single vision contact lenses with non-refractive opaque features.

Clinical & experimental optometry·2026
Same author

Contact lenses with non‑refractive opaque features for paediatric myopia: a randomised, safety pilot trial.

Eye (London, England)·2026
Same author

REPLY.

Ophthalmology·2026
Same author

Visual performance of phase alteration utilizing sub-elements lenses for potential myopia management.

Optometry and vision science : official publication of the American Academy of Optometry·2026
Same author

Visual performance of spectacle films utilising opaque, non-refractive features for potential myopia management.

Clinical & experimental optometry·2026

Related Experiment Video

Updated: Feb 5, 2026

Multifocal Electroretinograms
16:49

Multifocal Electroretinograms

Published on: December 4, 2011

18.9K

Association between multifocal soft contact lens decentration and visual performance.

Cathleen Fedtke1, Klaus Ehrmann1,2, Varghese Thomas1

  • 1The Brien Holden Vision Institute, Clinical Trial Research Centre, r.bakaraju@brienholdenvision.org.

Clinical Optometry
|September 15, 2018
PubMed
Summary

Multifocal soft contact lens (MFCL) decentration varied by design, impacting visual performance, especially in non-presbyopic individuals. Increased decentration correlated with decreased vision in this group.

Keywords:
decentrationhigher-order aberrationsmultifocal contact lensesvision

More Related Videos

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
11:49

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

13.2K
Author Spotlight: Advancing Understanding of Age-Related Lens Stiffness Changes
05:19

Author Spotlight: Advancing Understanding of Age-Related Lens Stiffness Changes

Published on: April 5, 2024

2.8K

Related Experiment Videos

Last Updated: Feb 5, 2026

Multifocal Electroretinograms
16:49

Multifocal Electroretinograms

Published on: December 4, 2011

18.9K
Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
11:49

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

13.2K
Author Spotlight: Advancing Understanding of Age-Related Lens Stiffness Changes
05:19

Author Spotlight: Advancing Understanding of Age-Related Lens Stiffness Changes

Published on: April 5, 2024

2.8K

Area of Science:

  • Ophthalmology
  • Optometry
  • Vision Science

Background:

  • Multifocal soft contact lenses (MFCLs) are widely used to correct presbyopia.
  • Lens decentration, the misalignment of the lens optic with the pupil center, can potentially affect visual performance.
  • Understanding the relationship between MFCL decentration and visual outcomes is crucial for optimizing lens design and patient satisfaction.

Purpose of the Study:

  • To investigate the association between the decentration of various commercial MFCLs and objective/subjective visual performance in presbyopic and non-presbyopic individuals.
  • To compare lens-induced aberrations and their correlation with decentration across different MFCL designs.
  • To identify specific MFCLs that exhibit significant decentration and evaluate its impact on visual acuity and subjective vision quality.

Main Methods:

  • Bilateral fitting of MFCLs and single vision control lenses in presbyopic (>40 years, near add ≥+1.25 D) and non-presbyopic (≥18 years) participants.
  • Objective measurement of lens decentration (x- and y-differences) and third-order aberrations.
  • Analysis of high- and low-contrast acuities and subjective visual variables for correlation with MFCL decentration using Pearson's correlation (r).

Main Results:

  • All tested MFCLs showed a temporal-inferior decentration. Proclear® MFCL Near and Distance lenses exhibited significant inferior decentration in specific groups.
  • Lens designs induced significant amounts of vertical coma; Proclear® MFCL Distance had more positive coma, while Proclear® MFCL Near had more negative coma.
  • A weak correlation between total MFCL decentration and vision variables was observed in presbyopic participants. In contrast, a moderate, significant correlation was found in non-presbyopic participants, indicating vision degradation with increased decentration.

Conclusions:

  • Specific MFCL designs demonstrate varying degrees of decentration and induce significant third-order aberrations.
  • A notable association between MFCL decentration and visual performance was identified in the non-presbyopic group, where lenses were more decentered.
  • The findings suggest that MFCL decentration plays a significant role in visual outcomes, particularly in individuals with larger pupils and lower inherent aberrations.