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Antidiabetic Activity of Afobazole in Wistar Rats.
R U Ostrovskaya1, S V Ivanov2, M V Voronin2
1V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. rita.ostrovskaya@gmail.com.
Bulletin of Experimental Biology and Medicine
|September 19, 2018
Summary
The anxiolytic drug Afobazole demonstrated significant antidiabetic effects in rats, comparable to metformin. Afobazole effectively managed hyperglycemia and improved body weight, offering a promising alternative for type 2 diabetes mellitus treatment.
Area of Science:
- Pharmacology
- Endocrinology
- Diabetology
Background:
- Type 2 diabetes mellitus (T2DM) is a growing global health concern.
- Current treatments for T2DM have limitations and side effects.
- Exploring novel therapeutic agents for T2DM is crucial.
Purpose of the Study:
- To compare the antidiabetic efficacy of Afobazole with metformin.
- To evaluate Afobazole's effects on key diabetes markers in a preclinical model.
Main Methods:
- Streptozotocin-induced type 2 diabetes mellitus model in Wistar rats.
- Administration of Afobazole (10 mg/kg) and metformin (300 mg/kg).
- Assessment of hyperglycemia, polyphagia, polydipsia, body weight, and malonic dialdehyde levels.
Main Results:
- Afobazole (10 mg/kg) significantly reduced hyperglycemia and polyphagia, comparable to metformin (300 mg/kg).
- Afobazole demonstrated superior efficacy in body weight recovery and polydipsia reduction.
- Afobazole's therapeutic effects persisted after treatment withdrawal, with reduced malonic dialdehyde accumulation.
Conclusions:
- Afobazole exhibits potent antidiabetic activity in a preclinical T2DM model.
- Afobazole is a viable alternative to metformin, showing comparable or superior efficacy.
- Further research into Afobazole for T2DM treatment is warranted.
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