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Published on: January 16, 2019
Antidiabetic Activity of Afobazole in Wistar Rats
R U Ostrovskaya1, S V Ivanov2, M V Voronin2
1V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. rita.ostrovskaya@gmail.com.
Abstract:
Using the streptozotocin model of type 2 diabetes mellitus in Wistar rats, we compared antidiabetic activity of anxiolytic Afobazole with that of metformin. Afobazole in a dose of 10 mg/kg reduced streptozotocin-induced hyperglycemia and polyphagia and prevented accumulation of malonic dialdehyde, being not inferior to metformin in a dose of 300 mg/kg, and was even more effective than metformin in body weight recovery, elimination of polydipsia, and preservation of these effects after treatment withdrawal.
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