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Updated: Feb 5, 2026
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
Naturally occurring change in Multiple Sclerosis Walking Scale-12 scores over time in multiple sclerosis
Robert W Motl1, Brian M Sandroff1, Edward McAuley2
1Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA 35294.
Aim:
This study examined the trajectory and pattern of naturally occurring change in perceived walking impairment over a 30-month period in relapsing-remitting multiple sclerosis (RRMS).
Patients & Methods:
Two hundred and sixty-nine persons with RRMS completed the 12-item Multiple Sclerosis Walking Scale (MSWS-12) every 6 months over a 30-month period. Data were analyzed using latent growth curve modeling and latent class growth curve modeling.
Results:
Latent growth curve modeling demonstrated that a linear trajectory adequately described the group-level pattern of change in MSWS-12 scores over time. Latent class growth curve modeling supported a three-class model for describing the heterogeneity of changes in MSWS-12 scores over time.
Conclusion:
Walking impairment does change over time in RRMS, and this can be described by three patterns of change trajectories that differed based on initial status of walking impairment.
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