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Updated: Feb 5, 2026

Author Spotlight: Studying Cardiac Cell-Matrix Interactions In Vitro
Published on: March 22, 2024
Natural Sources of Extracellular Matrix for Cardiac Repair
Keith L Spinali1, Eric G Schmuck2
1Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin Madison, Madison, WI, USA.
Abstract:
Tissue engineering and regenerative medicine have adopted the use of extracellular matrix (ECM) as a cell delivery device and bioactive regenerative agent. To this end, many ECMs have been investigated for cardiac tissue engineering and regenerative medicine applications with variable success. Many sources of natural ECMs have been tested for cardiac applications. Typically, natural ECMs have been made from decellularized organs or tissues and processed into either sheets or injectable hydrogels. This chapter will review natural sources of ECM materials that have been tested as therapeutic agents in models of heart failure.
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