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Related Experiment Video

Updated: Feb 5, 2026

Optogenetic Functional MRI

Optogenetic Functional MRI

Published on: April 19, 2016

Multi-modal functional MRI to explore placental function over gestation.

Jana Hutter^1,2, Paddy J Slator², Laurence Jackson^1,2

¹Centre for the Developing Brain, King's College London, United Kingdom.

Magnetic Resonance in Medicine

|September 23, 2018

Summary

This summary is machine-generated.

This study used advanced MRI to quantify human placenta physiology over gestation. Placental T2* and diffusivity decrease, while lacunarity increases, offering insights into pregnancy adaptation.

Keywords:

development diffusion MRI placenta postprocessing pregnancy complications relaxometry

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Area of Science:

Biomedical Imaging
Obstetrics
Fetal Medicine

Background:

The human placenta undergoes complex physiological changes throughout pregnancy.
Understanding placental development and function is crucial for monitoring fetal health.
Quantitative imaging can provide objective measures of placental health.

Purpose of the Study:

To investigate, visualize, and quantify human placental physiology.
To assess functional, temporal (over gestation), and spatial dimensions of the placenta.
To develop and apply advanced MRI techniques for placental assessment.

Main Methods:

Developed bespoke MRI techniques including diffusion protocols, T2* mapping, and anatomical imaging.
Employed a multi-modal pipeline with motion correction and quantitative feature extraction.
Scanned pregnant women (22-38 weeks gestation), including those with pre-eclampsia.

Main Results:

Demonstrated multi-faceted assessment of placental physiology.
Observed trends of increasing lacunarity over gestation.
Showed decreasing T2* values and diffusivity with advancing gestational age.

Conclusions:

Multi-modal MRI acquisition and quantification offer promising insights.
These methods can aid in studying placental evolution, adaptation, and compensation.
This approach has potential for monitoring high-risk pregnancies.