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Updated: Feb 4, 2026

Preparation of SNS CobaltII Pincer Model Complexes of Liver Alcohol Dehydrogenase
Published on: March 19, 2020
An NNN-Pincer-Cobalt Complex Catalyzed Highly Markovnikov-Selective Alkyne Hydrosilylation
Shaochun Zhang1, Jessica Juweriah Ibrahim1,2, Yong Yang1
1CAS Key Laboratory of Bio-Based Materials , Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences , Qingdao 266101 , China.
Abstract:
A new NNN pincer (amine-pyridine-imine, API) cobalt complex, which is bench-stable and is applicable for the highly efficient and regioselective hydrosilylation of terminal alkynes, is developed. A broad set of α-vinylsilanes was successfully synthesized in good to high yields with up to 98/2 Markovnikov regioselectivity. This protocol can be readily scaled up for gram-scale synthesis and demonstrates the most efficient cobalt-catalyzed hydrosilylation of alkynes with turnover frequencies as high as 126 720 h-1 to date.
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