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Circular RNAs as Novel Biomarkers for Cardiovascular Diseases

Qiulian Zhou1,2,3, Zhongrong Zhang2,3, Yihua Bei2,3

  • 1Shanghai Applied Radiation Institute, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China.

Advances in Experimental Medicine and Biology
|September 28, 2018
PubMed

Insights

Circular RNAs (circRNAs) show potential as novel biomarkers for cardiovascular diseases due to their stability and abundance. Research highlights their value in diagnosing conditions like heart failure and hypertension.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) are a leading global cause of mortality.
  • Early diagnosis and prognosis are crucial for effective CVD management.
  • Circular RNAs (circRNAs) are implicated in various disease pathologies and possess stable, abundant characteristics.

Purpose of the Study:

  • To review recent research on circRNAs.
  • To compare circRNAs with traditional biomarkers.
  • To evaluate the potential of circRNAs as biomarkers for cardiovascular diseases.

Main Methods:

  • Literature review of studies on circRNAs.
  • Comparative analysis of circRNA characteristics versus traditional biomarkers.
  • Focus on circRNAs in acute myocardial infarction, heart failure, coronary artery disease, and hypertension.

Main Results:

  • CircRNAs are stable and abundant molecules involved in disease processes.
  • CircRNAs exhibit potential as biomarkers across diverse diseases, including neurological disorders, cancers, and digestive diseases.
  • Specific circRNAs show promise for diagnosing and predicting outcomes in various cardiovascular conditions.

Conclusions:

  • CircRNAs represent a novel class of biomarkers with significant potential in cardiovascular medicine.
  • Their unique properties offer advantages over traditional biomarkers for CVD detection and prognosis.
  • Further research into circRNAs could revolutionize the diagnosis and treatment of cardiovascular diseases.

Keywords:
BiomarkersCardiovascular diseasesCircular RNA

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