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Relationship Between Cognitive Function and Clinical Features in Patients With Bipolar I Disorder
Oscar Mauricio Castaño Ramírez1, Sandra Milena Gómez Montoya1, Rocío Lemos Buitrago1
1Grupo de Investigación Salud Mental y Comportamiento Humano, Universidad de Caldas, Manizales, Colombia.
Early onset of bipolar I disorder (BP-I) and fewer years of education are linked to worse cognitive function. These factors appear to be significant risk factors impacting cognitive abilities in BP-I patients.
Area of Science:
- Neuroscience
- Psychiatry
- Clinical Psychology
Background:
- Cognitive dysfunction in bipolar I disorder (BP-I) correlates with impaired functioning and reduced quality of life.
- Altered cognitive function is linked to poorer BP-I prognosis, but its relationship with clinical features remains unclear.
Purpose of the Study:
- To investigate associations between cognitive function and clinical/socio-demographic factors in BP-I patients.
Main Methods:
- A neuropsychological battery assessed cognitive function in BP-I outpatients with no affective episodes for at least six months.
- Clustering methodology identified patients with best and worst cognitive function.
- Cognitive function clusters were correlated with clinical and socio-demographic variables.
Main Results:
- A significant correlation was found between years of education and cognitive function alterations (P=.002).
- A significant correlation was found between age of disorder onset and cognitive function alterations (P=.017).
- No other significant correlations were identified.
Conclusions:
- Fewer years of education is a risk factor for poorer cognitive function in BP-I.
- Early onset of bipolar I disorder is a risk factor for impaired cognitive function.
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