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PET/MRI in Breast Cancer
Akshat C Pujara1, Eric Kim2, Deborah Axelrod3
1Department of Radiology, Division of Breast Imaging, University of Michigan Health System, Ann Arbor, Michigan, USA.
Journal of Magnetic Resonance Imaging : JMRI
|October 7, 2018
Summary
Positron emission tomography / magnetic resonance imaging (PET/MRI) offers simultaneous PET and MRI data acquisition. This review explores PET/MRI
Area of Science:
- Hybrid imaging techniques
- Radiology and Nuclear Medicine
- Oncology imaging
Background:
- Positron emission tomography / magnetic resonance imaging (PET/MRI) integrates functional and anatomical imaging.
- Emerging technology with potential in various clinical applications.
- Technical requirements and evolving protocols are crucial for its implementation.
Purpose of the Study:
- To review the technical requirements, protocols, and tracers for PET/MRI.
- To discuss the potential of localized breast PET/MRI and whole-body PET/MRI in breast cancer management.
- To explore the application of advanced imaging metrics for treatment response prediction and precision medicine.
Main Methods:
- Review of existing literature on integrated and sequential PET/MRI scanners.
- Analysis of MRI sequence customization and radiotracer utilization (e.g., 18F-FDG, hypoxia, HER2 tracers).
- Evaluation of dedicated breast PET/MRI and whole-body PET/MRI applications in breast cancer.
Main Results:
- Sequential PET and MRI exams may provide similar clinical data to integrated PET/MRI.
- Dedicated breast PET/MRI may improve detection of nodal metastases compared to MRI alone.
- Whole-body PET/MRI shows potential for detecting more metastases at lower radiation doses than PET alone.
Conclusions:
- PET/MRI offers complementary information for breast cancer staging and treatment monitoring.
- Advancements in tracers and multiparametric analysis may enhance radiomics and precision medicine.
- Whole-body PET/MRI may be valuable for surveillance in specific patient populations.
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