Related Experiment Video
Updated: Feb 4, 2026

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
Published on: March 7, 2022
Human Tissue-Engineered Model of Myocardial Ischemia-Reperfusion Injury
Timothy Chen1, Gordana Vunjak-Novakovic1,2
11 Department of Biomedical Engineering, Columbia University in the City of New York, New York, New York.
Impact Statement:
Reducing ischemia-reperfusion injury would significantly improve patient survival. Current preclinical models are inadequate because they rely on animals, which do not emulate human physiology and the clinical setting. We developed a human tissue platform that allowed us to assess the human cardiac response, and demonstrated the platform's utility by measuring injury during ischemia-reperfusion and the effects of cardioprotective strategies. The model provides a foundation for future studies on how patient-specific backgrounds may affect response to therapeutic strategies. These steps will be necessary to help translate therapies into the clinical setting.
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